FDA Grants Blinatumomab Priority Review for Pediatric Acute Lymphoblastic Leukemia
The FDA has granted a priority review to an application to expand the approval of blinatumomab (Blincyto) to include the treatment of pediatric and adolescent patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Steroid Use With Abiraterone Offers Multidimensional Benefits to Patients With mCRPC
Abiraterone acetate, alone or in combination with low-dose steroids, has been intensely investigated in recent years for the treatment of progressive CRPC in patients who have received prior chemotherapy or who were treatment-naïve.
Germline Genetic Testing Raises Thorny Ethical Questions
If germline testing for a cancer-associated purpose reveals the risk of an unrelated illness like Alzheimer disease, should patients routinely be told—even if there’s nothing that can be done about that “incidental” finding?
From the Editor
Expert Shares Insight on Promising Entinostat/IL-2 Results in RCC
Robert Pili, MD, discusses the results and significance of an early-phase trial looking at the combination of entinostat and interleuken-2 and how it could shake up the treatment paradigm for renal cell carcinoma.
Dalla-Favera’s Research Sets Stage for Lymphoma Advances
Riccardo Dalla-Favera, MD, whose work has helped characterize the molecular drivers of B-cell lymphomas, was honored in the Lymphoma category with a 2014 Giants of Cancer Care® award, a program that the Intellisphere® Oncology Specialty Group launched to honor leaders in the field.
Combining Vismodegib With Radiation May Benefit Patients With Basal Cell Carcinoma
Chris Barker, MD, discusses a study investigating radiation therapy plus the hedgehog pathway inhibitor vismodegib (Erivedge) in patients with locally advanced basal cell carcinoma of the head and neck.
Early Intervention With Lenalidomide Examined in Smoldering Myeloma
In an ongoing randomized phase III trial, researchers are looking at lenalidomide (Revlimid) compared with observation in patients with asymptomatic high-risk smoldering multiple myeloma.
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