James N. Kochenderfer, MD, Experimental Transplantation and Immunology Branch, National Cancer Institute in Bethesda, MD, discusses the B-cell antigen CD19 and its role in chemotherapy-resistant B-cell malignancies. At the 53rd Annual Meeting of the American Society of Hematology, held at the San Diego Convention Center, Kochenderfer presented data on 8 patients treated with an anti-CD19 chimeric antigen receptor. While the agent did cause some toxicity in patients, it was able to eliminate targeted cells.


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