Tomasz Beer, MD, FACP, professor of Medicine, deputy director of the Knight Cancer Institute, Oregon Health and Science University, discusses the treatment of metastatic castration-resistant prostate cancer (mCRPC) with abiraterone and enzalutamide as it relates to results from the PREVAIL study.
Beer says that is a wonderful time to contemplate how two effective drugs could both be used for patients in this space. As the PREVAIL study was not designed to compare abiraterone and enzalutamide, it cannot be said that one drug is superior or inferior.
A decision to treat with abiraterone or enzalutamide must be made on a physician-by-physician and patient-by-patient basis as there are specific considerations to be made. For example, Beer notes, enzalutamide does not require steroids, so for patients for whom giving steroids is a concern, enzalutamide may be preferred.
Beer says that there are many differences in the two studies and the data that may help a physician make decisions.
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