Bringing the Oncology Community Together

Dr. Kris on Dacomitinib in EGFR-Positive Lung Cancer

Mark G. Kris, MD
Published Online: Wednesday, December 12, 2012
Mark G. Kris, MD, chief of the Thoracic Oncology Service at Memorial Sloan-Kettering Cancer Center, discusses the initial trials studying dacomitinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), in patients with EGFR-mutant lung cancers.

Kris explains that dacomitinib was first studied in hopes that a greater, potentially permanent, tumor shrinkage would occur. A phase II study compared dacomitinib to reversible TKIs such as gefitinib and erlotinib as a first-line treatment for patients with lung cancers. The partial response rate was 74% among patients with EGFR deletions at exons 19 and 21. At one year, progression-free survival (PFS) rate was 77% and median PFS was 17 months.

Dacomitib may be as effective as gefitinib in terms of degree and length of tumor shrinkage, Kris believes.

Related Articles
First- and Later-line Use of Panitumumab in mCRC
Panelists describe the results of clinical trials of the EGFR inhibitor panitumumab as first-line or later-line therapy for patients with metastatic colorectal cancer and the importance of RAS testing for patient selection.
Pancoast Tumors of the Lung: Improved Results
Every patient with a pancoast tumor of the lung should be evaluated by a Pancoast-experienced thoracic surgeon (and neurosurgeon) before ruling out surgery, and before starting induction therapy.
Next-Generation Targeted Therapies in NSCLC
In this segment, panelists discuss the number of early-phase clinical trials that have demonstrated impressive efficacy for next-generation ALK and EGFR inhibitors for patients with non-small cell lung cancer.
Most Popular Right Now
More Reading
External Resources

American Journal of Managed Care
HCPLive
PainLive
Pharmacy Times
Physicians' Education Resource
Physician's Money Digest
Specialty Pharmacy Times
TargetedOnc
OncLive Resources

Archives
Blogs
OncLive TV
Oncology Nurses
Publications
Specialties
Web Exclusives


About Us
Advertise
Advisory Board
Contact Us
Forgot Password
Privacy Policy
Terms & Conditions
Intellisphere, LLC
666 Plainsboro Road
Building 300
Plainsboro, NJ 08536
P: 609-716-7777
F: 609-716-4747

Copyright OncLive 2006-2014
Intellisphere, LLC. All Rights Reserved.