Dr. Nielsen on the Pros and Cons of the Ki67 Assay

Torsten O. Nielsen, MD, PhD, FRCPC
Published Online: Thursday, September 26, 2013
Torsten O. Nielsen, MD, PhD, FRCPC, a professor of pathology at the University of British Columbia, discusses the pros and cons of using the Ki67 as a prognostic marker in breast cancer.

Nielsen says there is extensive literature on the clinical validity of Ki67. It is a marker of proliferation that assists in the prognosis of breast cancer and many believe an assay could have a role in the prediction of the disease. Nielsen also notes that testing for Ki67 could be a substitute for a more complex, expensive test.

However, the Ki-67 tumor marker test is not without problems, Nielsen says. There is poor analytical reproducibility with Ki67 scores, especially within the critical 10-20% range.

Although the fundamentals of the assay work well, Nielsen says, the scoring and interpretation of the test are difficult to reproduce.

Online CME Activities
Free CME from PER
9th Annual Multidisciplinary Symposium on Head and Neck CancerĀ® Medical CrossfireĀ®
Clinical Challenges in the Management of Melanoma
Advances in ImmunoOncology: Intralesional Oncolytic Immunotherapy in Melanoma
Updates in the Treatment of Lung Cancer
More Reading
$auto_registration$