Bringing the Oncology Community Together

Dr. Wetzler Discusses the Use of Arsenic Trioxide in APL

Meir Wetzler, MD
Published Online: Tuesday, March 26, 2013
Meir Wetzler, MD, Chief, Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, discusses a study presented at the 2012 American Society of Hematology Meeting analyzing arsenic trioxide in acute promyelocytic leukemia (APL).

Wetzler notes that APL was a deadly disease until ATRA came along in the 1970s. Since then, it has been used with chemotherapy to improve survival.

The phase III trial APL0406 trial looked at all trans-retinoic acid (ATRA) and arsenic trioxide compared to ATRA and idarubicin for newly diagnosed patients with non high-risk APL.

In this trial, after a median follow-up of 31 months, the two-year event-free survival was 97% (95% CI, 93.1–100) in the ATRA + arsenic trioxide arm and 86.7% (95% CI, 80.3–93.6) in the ATRA + idarubicin arm (P = 0.03). In this population, front-line treatment with arsenic trioxide and ATRA without chemotherapy is not inferior.

Related Articles
New MRD Assay Helps Move Testing Forward in Multiple Myeloma Research
An improved assay for assessing MRD status in patients with multiple myeloma is contributing to the momentum for using MRD as a surrogate endpoint for survival in clinical trials and as a tool with the potential to help guide therapy choices.
FDA Approves First-Line Ofatumumab for Fludarabine-Ineligble Patients With CLL
The FDA has approved ofatumumab plus chlorambucil for previously untreated patients with chronic lymphocytic leukemia who are considered inappropriate for treatment with fludarabine therapy.
Epizyme Maintains Independence, Advances HMT-Inhibitor Platform
Epizyme, a Cambridge, Massachusetts-based biotech, opted for independence, with a successful IPO in 2013.
Most Popular Right Now
More Reading
External Resources

American Journal of Managed Care
Pharmacy Times
Physicians' Education Resource
Physician's Money Digest
Specialty Pharmacy Times
OncLive Resources

OncLive TV
Oncology Nurses
Web Exclusives

About Us
Advisory Board
Contact Us
Forgot Password
Privacy Policy
Terms & Conditions
Intellisphere, LLC
666 Plainsboro Road
Building 300
Plainsboro, NJ 08536
P: 609-716-7777
F: 609-716-4747

Copyright OncLive 2006-2014
Intellisphere, LLC. All Rights Reserved.