Jerry Lanchbury, PhD, Describes Myriad's HRD Test

Jerry Lanchbury, PhD
Published Online: Friday, January 3, 2014
Jerry Lanchbury, PhD, chief scientific officer, Myriad Genetics, Inc., describes the HRD (homologous recombination deficiency) test.

One fundamental defect of a number of tumors is that they lack the ability to repair double-strand breaks in DNA. This defect, Lanchbury says, is why the BRCA1/2 gene causes hereditary breast and ovarian cancer.

There are 3 versions of the HRD test: whole genome tumor loss of heterozygosity profiles (HRD-LOH), telomeric allelic imbalance (HRD-TAI), and large-scale state transitions (HRD-LST). These 3 tests are closely correlated but are not the same, and see a fundamental property of the tumor. When combined, these tests are extremely useful in detecting sensitivity to platinum. In the future, these tests might also be used to determine which patients will be sensitive to PARP inhibitors that are currently in development.

Online CME Activities
Free CME from PER
Advances in the Treatment of Metastatic Colorectal Cancer
Renal Cell Carcinoma: Recent Advances, New Questions
Community Practice Connections™: Working Group to Advance the Treatment of Triple-Negative Breast Cancer: Examining the Evidence and Looking to the Future
Community Practice Connections™: 10th Annual New York Lung Cancer Symposium®
More Reading
$auto_registration$