Dr. Ginsburg on Determining Genetic Testing in Gynecologic Malignancies

Ophira M. Ginsburg, MSc, MD, FRCPC
Published Online: Thursday, Oct 12, 2017



Ophira M. Ginsburg, MSc, MD, FRCPC, director of the High Risk/Cancer Genetics Program at NYU Langone's Perlmutter Cancer Center, discusses determining which patients should receive genetic testing for gynecologic malignancies.

Women in families with MSH2 germline mutation for Lynch syndrome need to be counseled, especially if they test positive for the mutation, states Ginsburg. These women have a very high risk of uterine cancer and endometrial cancer. Additionally, the risk of uterine cancer in those families is higher than the risk of ovarian cancer.

As there is no proven way to screen for uterine cancer, there is a suggestion that random sampling of the endometrium may have some value. Uterine cancer can also be associated with PTEN mutation, which has risks of breast, uterine, and other cancers. This is an emerging area of gynecologic oncologic genetics, explains Ginsburg.



Ophira M. Ginsburg, MSc, MD, FRCPC, director of the High Risk/Cancer Genetics Program at NYU Langone's Perlmutter Cancer Center, discusses determining which patients should receive genetic testing for gynecologic malignancies.

Women in families with MSH2 germline mutation for Lynch syndrome need to be counseled, especially if they test positive for the mutation, states Ginsburg. These women have a very high risk of uterine cancer and endometrial cancer. Additionally, the risk of uterine cancer in those families is higher than the risk of ovarian cancer.

As there is no proven way to screen for uterine cancer, there is a suggestion that random sampling of the endometrium may have some value. Uterine cancer can also be associated with PTEN mutation, which has risks of breast, uterine, and other cancers. This is an emerging area of gynecologic oncologic genetics, explains Ginsburg.


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