Dr. Holmes Discusses Late Recurrence and the MA.17R Trial in Breast Cancer

Frankie Ann Holmes, MD
Published: Friday, Jul 29, 2016


Frankie Ann Holmes, MD, a physician at Texas Oncology, discusses the MA.17R trial, which evaluated how long treatment with aromatase inhibitors should be given to patients with early-stage breast cancer.
 
In the trial, patients were randomized to receive continued use of letrozole or placebo after receiving 5 years of letrozole.
 
At a median follow-up of 10 years, an overview of the study showed that there was a continued recurrence out to 20 years. This is still relatively early in the natural history of the disease, and more relapses could still occur, says Holmes.
 
A risk analysis needs to be conducted to determine which patients are at the greatest risk of late recurrence. The Breast Cancer Index (BCI) is one tool that is used in practice to predict risk. This and other tools will help oncologists individualize and personal treatment for each patient.
 

Frankie Ann Holmes, MD, a physician at Texas Oncology, discusses the MA.17R trial, which evaluated how long treatment with aromatase inhibitors should be given to patients with early-stage breast cancer.
 
In the trial, patients were randomized to receive continued use of letrozole or placebo after receiving 5 years of letrozole.
 
At a median follow-up of 10 years, an overview of the study showed that there was a continued recurrence out to 20 years. This is still relatively early in the natural history of the disease, and more relapses could still occur, says Holmes.
 
A risk analysis needs to be conducted to determine which patients are at the greatest risk of late recurrence. The Breast Cancer Index (BCI) is one tool that is used in practice to predict risk. This and other tools will help oncologists individualize and personal treatment for each patient.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Vignette Series: 34th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow®Feb 28, 20182.0
34th Annual Miami Breast Cancer Conference® Clinical Case Vignette Series™May 25, 20182.0
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