Dr. Kulke on Emerging Cabozantinib Data for NETs

Video

Matthew H. Kulke, MD, Dana-Farber Cancer Institute, discusses the emerging data seen with cabozantinib (Cabometyx) for patients with neuroendocrine tumors (NETs).

Matthew H. Kulke, MD, Dana-Farber Cancer Institute, discusses the emerging data seen with cabozantinib (Cabometyx) for patients with neuroendocrine tumors (NETs).

There are several new treatments that are focused on tumor control for patients with NETs, says Kulke. There was a phase II study of cabozantinib, which targets the VEGF receptor and c-MET.

Phase II studies show encouraging results, explains Kulke. Based on those results, cabozantinib is going to be taken forward into a large randomized study that is designed as a registrational study.

Partial responses were observed in 15% of each cohort treated with cabozantinib, and stable disease was the best response in about two-thirds of patients. Median progression-free survival exceeded 20 months in patients with pancreatic NETs and was >30 months in the carcinoid tumor cohort.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Minesh Mehta, MD
Ruben Olivares, MD
Phillip J. Koo, MD