Dr. O'Shaughnessy on Precision Medicine in Triple Negative Breast Cancer

Joyce O'Shaughnessy, MD
Published Online: Tuesday, Sep 13, 2016



Joyce O'Shaughnessy, MD, co-chair, breast cancer research, chair breast cancer at Baylor University Medical Center, discusses precision medicine in triple negative breast cancer (TNBC).

For TNBC, there is a group of patients who really benefit in the metastatic setting from the use of cisplatin or carboplatin, says O'Shaughnessy. A specific phenotype of those patients—particularly those who recur in other locations, such as the lung or lymph nodes—have a very high Ki-67 and tend to benefit tremendously from platinum-based therapy.

Some types of TNBC are a bit more indolent, explains O'Shaughnessy. About 20% of these more slow-growing cancers have the androgen receptor, which is an important detail for oncologists to keep in mind, especially when it comes to clinical trial participation.

There are a number of emerging, promising therapies and therapeutic hypotheses that are currently being investigated, and significant progress in this space is expected over the next 5 years, says O'Shaughnessy.


Joyce O'Shaughnessy, MD, co-chair, breast cancer research, chair breast cancer at Baylor University Medical Center, discusses precision medicine in triple negative breast cancer (TNBC).

For TNBC, there is a group of patients who really benefit in the metastatic setting from the use of cisplatin or carboplatin, says O'Shaughnessy. A specific phenotype of those patients—particularly those who recur in other locations, such as the lung or lymph nodes—have a very high Ki-67 and tend to benefit tremendously from platinum-based therapy.

Some types of TNBC are a bit more indolent, explains O'Shaughnessy. About 20% of these more slow-growing cancers have the androgen receptor, which is an important detail for oncologists to keep in mind, especially when it comes to clinical trial participation.

There are a number of emerging, promising therapies and therapeutic hypotheses that are currently being investigated, and significant progress in this space is expected over the next 5 years, says O'Shaughnessy.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Integrating CDK4/6 Inhibitors into the Management of Breast CancersMay 26, 20171.5
Community Practice Connections™: A Team-Based Approach to Enhanced Recovery: Controlling Postsurgical Pain in Breast Cancer PatientsJun 29, 20172.0
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