Dr. Powell on CPI-613, Cytarabine, Mitoxantrone Combo for AML

Bayard L. Powell, MD
Published Online: Friday, Jan 09, 2015

Bayard L. Powell, MD, Section Chief of Hematology and Oncology and Director of Leukemia Services at Wake Forest University Baptist Medical Center, discusses using the mitochondrial metabolism inhibitor CPI-613 in combination with high-dose cytarabine and mitoxantrone for relapsed or refractory acute myeloid leukemia (AML).

The results of the recent phase I study look promising. The combination has been effective, with 54% of patients showing a response and no increased toxicity occurring from the addition of CPI-613. The combination was particularly beneficial for patients over 60 and patients with poor risk cytogenetics, says Powell.

Bayard L. Powell, MD, Section Chief of Hematology and Oncology and Director of Leukemia Services at Wake Forest University Baptist Medical Center, discusses using the mitochondrial metabolism inhibitor CPI-613 in combination with high-dose cytarabine and mitoxantrone for relapsed or refractory acute myeloid leukemia (AML).

The results of the recent phase I study look promising. The combination has been effective, with 54% of patients showing a response and no increased toxicity occurring from the addition of CPI-613. The combination was particularly beneficial for patients over 60 and patients with poor risk cytogenetics, says Powell.




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