Dr. Richter Discusses the Administration of Carfilzomib

Joshua Richter, MD
Published: Monday, Mar 24, 2014

Joshua Richter, MD, hematologist/oncologist, multiple myeloma, John Theurer Cancer Center, discusses the administration of carfilzomib.

Carfilzomib is a new, highly active agent approved for the treatment of patients with myeloma. Currently, carfilzomib is administered at doses up to 27 mg/m2 over 2-10 minutes, though many physicians are switching to 30-minute infusion times. The rationale for this switch is that preclinical models have shown that the toxicity is related to peak dosing. By stretching out the infusion time, higher doses may be given with reduced toxicity, Richter says.

A clinical trial will look at escalating doses of carfilzomib up to 80 mg/m2 by extending to 1-hour infusion.

Joshua Richter, MD, hematologist/oncologist, multiple myeloma, John Theurer Cancer Center, discusses the administration of carfilzomib.

Carfilzomib is a new, highly active agent approved for the treatment of patients with myeloma. Currently, carfilzomib is administered at doses up to 27 mg/m2 over 2-10 minutes, though many physicians are switching to 30-minute infusion times. The rationale for this switch is that preclinical models have shown that the toxicity is related to peak dosing. By stretching out the infusion time, higher doses may be given with reduced toxicity, Richter says.

A clinical trial will look at escalating doses of carfilzomib up to 80 mg/m2 by extending to 1-hour infusion.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 1st Annual European Congress on Hematology™: Focus on Lymphoid MalignanciesJan 30, 20182.0
Medical Crossfire®: The Expanding Role of PARP Inhibitors in the Treatment of Ovarian Cancers – Current Strategies and Future DirectionJan 30, 20181.5
Publication Bottom Border
Border Publication
x