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Management of mTOR Inhibitor Side Effects in Breast Cancer

Panelists: Adam M. Brufsky, MD, PhD, University of Pittsburgh; Sara Hurvitz, MD, UCLA;Joyce A. O'Shaughnessy, MD, US Oncology; Edith A. Perez, MD,
Published Online: Wednesday, Jun 19, 2013
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Managing the side effects associated with mTOR inhibition is a novel endeavor for many breast oncologists. As such, they must grow familiar with techniques for managing these unique side effects. Along these lines, Andrew D. Seidman, MD, recommends a work published by his colleague Mario E. Lacouture, MD, on the management of dermatologic issues associated with mTOR inhibition.

To avoid unwarranted side effects and optimize response to treatment, researchers are exploring correlative markers that predict response to mTOR inhibition. A few studies examining these markers were presented at the 2013 ASCO Annual Meeting, Hope S. Rugo, MD, notes. Markers are intriguing to most members of the panel, Edith A. Perez, MD, suggests. However, it is important that large data sets are utilized to identify and validate new markers, particularly to avoid inaccurate findings.

The management of mTOR inhibitor-induced hypertriglyceridemia is a novel undertaking for some breast oncologists, Seidmen believes. Fortunately, downstream effects, such as pancreatitis, do not commonly manifest but the management of this side effect, as well as hyperglycemia, warrants the awareness of treating physicians. As further trials exploring everolimus in breast cancer are completed, such as BOLERO-3, the management of these unique side effects grows more important, notes Adam M. Brufsky, MD, PhD.

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For High-Definition, Click
Managing the side effects associated with mTOR inhibition is a novel endeavor for many breast oncologists. As such, they must grow familiar with techniques for managing these unique side effects. Along these lines, Andrew D. Seidman, MD, recommends a work published by his colleague Mario E. Lacouture, MD, on the management of dermatologic issues associated with mTOR inhibition.

To avoid unwarranted side effects and optimize response to treatment, researchers are exploring correlative markers that predict response to mTOR inhibition. A few studies examining these markers were presented at the 2013 ASCO Annual Meeting, Hope S. Rugo, MD, notes. Markers are intriguing to most members of the panel, Edith A. Perez, MD, suggests. However, it is important that large data sets are utilized to identify and validate new markers, particularly to avoid inaccurate findings.

The management of mTOR inhibitor-induced hypertriglyceridemia is a novel undertaking for some breast oncologists, Seidmen believes. Fortunately, downstream effects, such as pancreatitis, do not commonly manifest but the management of this side effect, as well as hyperglycemia, warrants the awareness of treating physicians. As further trials exploring everolimus in breast cancer are completed, such as BOLERO-3, the management of these unique side effects grows more important, notes Adam M. Brufsky, MD, PhD.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Assessing the Clinical Potential for Immunotherapies in the Treatment of Breast CancerFeb 22, 20171.0
Community Practice Connections™: Working Group to Advance the Treatment of Triple-Negative Breast Cancer: Examining the Evidence and Looking to the FutureFeb 28, 20171.5
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