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Soft Tissue Sarcoma

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Discovery Dilemma: Narrow “Superiority” Standard Is an Inferior Way to Evaluate Novel Therapies
Discovery Dilemma: Narrow “Superiority” Standard Is an Inferior Way to Evaluate Novel Therapies
The lack of documented superiority in a given randomized oncology trial may not indicate the absence of clinical utility but rather the presence of equivalent favorable activity for each of the two agents.
Novel Imaging Identifies Changes in Osteosarcoma Earlier in Treatment
Novel Imaging Identifies Changes in Osteosarcoma Earlier in Treatment
A novel imaging technology was able to determine four days after treatment that experimental therapies for sarcoma were fighting the cancer in xenograft models
Updated Results Confirm Aldoxorubicin Superiority in STS
Updated Results Confirm Aldoxorubicin Superiority in STS
Aldoxorubicin demonstrated significant benefit to progression-free survival (PFS) compared with doxorubicin in patients with first-line, metastatic, locally advanced or unresectable soft tissue sarcomas
Early Data Show Patients With STS May Benefit From Belinostat
Early Data Show Patients With STS May Benefit From Belinostat
Final results from the first stage of the phase II portion of the phase I/II CLN-14 clinical trial analyzing belinostat (PXD101) in combination with doxorubicin in patients with soft tissue sarcomas (STS) demonstrated that the novel agent could provide benefit in this space
Aldoxorubicin More Effective Than Doxorubicin in Soft Tissue Sarcomas
Aldoxorubicin More Effective Than Doxorubicin in Soft Tissue Sarcomas
Aldoxorubicin (formerly INNO-206) has demonstrated response rates that culminated in a higher incidence of stable disease when compared to doxorubicin as a first-line treatment for patients with advanced soft tissue sarcomas.
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