Oncology Articles

Varlitinib Misses PFS, ORR Endpoints in Biliary Tract Cancer
Varlitinib combined with capecitabine did not improve progression-free survival nor overall response rate compared with capecitabine/placebo as a second-line treatment in patients with biliary tract cancer.
NGS Testing Is Essential Before Induction in NSCLC
Suresh S. Ramalingam, MD, FASCO, highlights current and emerging therapies for 6 key actionable driver mutations in non–small cell lung cancer.
Plasma NGS Demonstrating Practice-Changing Potential in NSCLC
Plasma genotyping is the next big thing in non–small cell lung cancer, and it's already impacting clinical practice.
Osimertinib Positioned as Preferred Frontline Treatment for <em>EGFR</em>-Mutant NSCLC
Zofia Piotrowska, MD, MHS, discusses the role of osimertinib in treating patients with EGFR-mutant non–small cell lung cancer and how it compares with other therapeutic options in that space.
Frontline Immunotherapy Firmly Established for Select Patients With NSCLC
The use of immunotherapy, either as monotherapy or in combination with chemotherapy, continues to raise the bar with regard to overall survival benefit in patients with newly diagnosed, advanced nonsquamous non–small cell lung cancer.
FDA Grants Priority Review to Nivolumab/Ipilimumab in Advanced HCC
The FDA has granted a priority review designation to a supplemental biologics license application for the combination of nivolumab and ipilimumab for the treatment of patients with advanced hepatocellular carcinoma who received prior therapy with sorafenib.
Prognostic and Predictive Assays Guide Therapy Decisions in Breast Cancer
Joseph A. Sparano, MD, discusses using gene expression profiles as a means to guide therapy in breast cancer. 
Rapid Progress in HCC Leads to Sequencing Challenges
Andreas Kaubisch, MD, sheds light on systemic therapies available in liver cancer and some of the practice-changing phase III trials that have read out in the space.
Role of Neoadjuvant Immunotherapy Being Refined in Resectable NSCLC
Neoadjuvant immunotherapy can offer promise to patients with resectable non–small cell lung cancer, but further investigation is required for optimal use, Tina Cascone, MD, PhD, said in a presentation during the 14th Annual New York Lung Cancers Symposium®.
Neoadjuvant Approaches Showcase Advantages in NSCLC
Based on efficacy, tolerability, and practicality, neoadjuvant therapy in lung cancer offers significant advantages over adjuvant treatment, said Jamie E. Chaft, MD, in a presentation during the 14th Annual New York Lung Cancers Symposium®. However, she added, adjuvant treatment predominantly remains the standard of care at many cancer centers, she said.
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