Precision Medicine in Oncology® Articles

Study Validates Speed, Accuracy of Liquid Biopsies Identifying NSCLC Biomarkers
A liquid biopsy test detected all of the guideline-recommended biomarkers in newly diagnosed patients with metastatic non–small cell lung cancer at a similar rate but faster turnaround time to that of tissue genotyping.
Process Gets Overlooked in the Obsession With Outcomes in Oncology
It is essential to appreciate that precision cancer medicine is a process, not an event.
Thanks to technological advances, the past several decades have witnessed a blossoming appreciation of the varied composition of these microbial communities, their complex and dynamic relationship with the host, and the way they affect health and disease.
Massimo Cristofanilli, MD, discusses the clinical utility of liquid biopsies—specifically focusing on circulating tumor cells and cell-free DNA—and highlights ongoing research in the space.
cfDNA Cancer Detection Remains Viable, But Requires Further Validation
Geoffrey R. Oxnard, MD, discusses the use of cell-free DNA as a potential method of cancer detection and subsequent assessment of treatment response in patients with solid and hematologic malignancies.
Further Evidence Needed Supporting Clinical Utility of Liquid Biopsies in GI Cancers
John Strickler, MD, discusses how liquid biopsies are being used to help guide treatment decisions for patients with GI cancers and shed light on other research efforts that are being made to improve outcomes.
Lung-MAP Trial Expands to Include All Patients With NSCLC
The Lung Cancer Master Protocol, known as the first precision medicine trial in lung cancer supported by the National Cancer Institute, has expanded to include patients with all types of non–small cell lung cancers.
Novel Agents Aimed at Disrupting Cancer Metabolism Gain Ground
Since the Warburg effect has been observed in the majority of cancer types, many studies have focused on developing therapies that target metabolic pathways.
Cancer cells must maintain a delicate balance to prevent catastrophic levels of DNA damage from triggering cell death, and their heavy reliance on the remaining normal DNA damage response components creates a therapeutically targetable Achilles’ heel.
Maurie Markman, MD, discusses how to address the important issue of survival following a cancer diagnosis. 
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