Precision Medicine in Oncology® Articles | Page 2

Expert Highlights Evolving Options in HER2+ Breast Cancer
Tiffany A. Traina, MD, discusses her experiences with using neratinib and pertuzumab, and shares her excitement on the direction in which the HER2-positive breast cancer field is moving.
Network Enlists Practicing Oncologists to Develop Plans
Physicians are carefully evaluating potential partnership and referral deals to ensure that whatever they do is perceived as aligned with delivering better, more efficient care.
The FDA’s recent approvals of novel anti-PARP agents as maintenance therapy for patients with previously treated advanced ovarian cancer highlight an issue that has received inadequate attention in the peer-reviewed oncology literature.
The trastuzumab (Herceptin) biosimilar SB3 induced a rate of breast pathologic complete response similar to trastuzumab in women with HER2-positive breast cancer, according to results from a phase III study of 800 patients.
Study Finds No Cardiac Toxicity Increase With Trastuzumab in HER2+ Breast Cancer Patients
Trastuzumab did not reduce cardiac function in women with node-positive, HER2+, early-stage breast cancer.
FDA Expands Afatinib's Approval for Lung Cancer
The FDA has expanded the frontline indication for afatinib to include the treatment of patients with metastatic non–small cell lung cancer whose tumors harbor uncommon EGFR alterations in L861Q, G719X, and/or S768I.
 
Novel Treatments Emerging in HER2+ Breast Cancer Pipeline
Aleix Prat, MD, PhD, discusses the novel treatments being developed in the paradigm of HER2-positive breast cancer.
Pertuzumab and Other Agents Continue Progress in HER2+ Breast Cancer
Adam M. Brufsky, MD, PhD, discusses the developing role of pertuzumab in HER2-positive breast cancer, as well as the impact of other agents in the field.
Dual HER2 Blockade Superior for PFS in HER2+/HR+ Metastatic Breast Cancer
The combination of lapatinib, trastuzumab, and an aromatase inhibitor (AI) reduced the risk for death or progression by 38% in women with HER2+/HR+ metastatic breast cancer compared with those treated with a targeted agent plus AI.
Long-Term Data Published for Neratinib in HER2+ Breast Cancer
Extended adjuvant therapy with neratinib significantly reduced the proportion of clinically relevant breast cancer relapses without increasing the risk of long-term toxicity.
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