Colorectal Cancer Articles

Novel Therapy May Boost Efficacy of Chemotherapy Backbone in mCRC
In a phase III trial, investigators are examining if arfolitixorin can supplant leucovorin calcium, a widely used component of combination regimens in patients with metastatic colorectal cancer.
Ryan B. Corcoran, MD, PhD, discusses emerging therapeutics for patients with relapsed/refractory colorectal cancer.
Wnt Pathway Emerges as Attractive Target in CRC
Lukas E. Dow, PhD, discusses ongoing research evaluating Wnt as a potential target in colorectal cancer.
Genetic Testing Guides mCRC Treatment
Al B. Benson, MD, discusses personalized treatment strategies for patients with metastatic colorectal cancer.
Hepatic Infusion Can Convert CRC Liver Metastases to Operable State
Overall, compelling response rates and rates of conversion to resection for patients with initially unresectable colorectal liver metastases treated with hepatic arterial infusion suggest consideration of earlier initiation of the technique in chemotherapy-naïve patients as well as its adoption in patients who have failed first-line systemic chemotherapy before proceeding to second- or third-line regimens.
The investigational KRAS G12C inhibitor MRTX849 demonstrated clinical activity in patients with non–small cell lung cancer and colorectal cancer.
Addressing the Needs of Molecular Subgroups in CRC
Benjamin Weinberg, MD, discusses the treatment options available for the various subpopulations in metastatic colorectal cancer.
Pivotal Study Examines Blood Test as CRC Screening Method
In an effort to improve colorectal cancer screening rates via a less invasive method, the registrational ECLIPSE is evaluating the performance of the LUNAR-2 blood test in detecting colorectal cancer in average-risk adults.
ATOMIC Looks at Immunotherapy in Early-Stage dMMR Colon Cancer
Investigators are seeking to determine whether immunotherapy that has been effective in metastatic colon cancers with deficient DNA mismatch repair can be applied to earlier-stage disease, specifically, nonmetastatic stage III colon cancer.
The FDA has expanded the approval of the noninvasive colorectal cancer (CRC) screening test Cologuard to include eligible at-risk individuals ≥45 years.
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