Genitourinary Cancers Articles

New Nivolumab Dosing Schedules Approved in Europe
The European Commission has approved 2 new dosing schedules for nivolumab across several tumor types.
Ramucirumab Misses OS Endpoint in Phase III Urothelial Carcinoma Trial
Combining ramucirumab with docetaxel in patients with locally advanced or unresectable metastatic urothelial carcinoma who progressed on platinum-based chemotherapy led to a positive trend, but not a statistically significant improvement, in overall survival. 
Rocapuldencel-T Falls Short in mRCC
An interim analysis revealed that the immunotherapy rocapuldencel-T is unlikely to meet any of the primary endpoints of the phase III ADAPT trial in patients with metastatic renal cell carcinoma. 
Anti-PD-1 Biomarker Analysis Shows Promise for MDSCs, IFN-Gamma
A search for molecular guidance in the use of anti-PD-1 therapy in urothelial cancer pointed toward myeloid-derived suppressor cells as a potentially useful biomarker.
FDA Approves Nivolumab/Ipilimumab for Frontline RCC
The FDA has approved the combination of nivolumab and ipilimumab as a frontline treatment for intermediate- and poor-risk patients with advanced renal cell carcinoma.
Treatment Developments Shaking Up Landscape for Nonmetastatic CRPC
Mark J. Mann, MD, discusses the developing treatment landscape for patients with nonmetastatic CRPC.
Adjuvant Axitinib Falls Short in Phase III RCC Trial
Adjuvant axitinib did not extend disease-free survival versus placebo for patients at high risk of recurrent renal cell carcinoma after nephrectomy, according to findings from the phase III ATLAS trial.
POUT Data Show Benefit of Adjuvant Chemotherapy in Patients With UTUC
Data from the phase III POUT clinical trial demonstrated that adjuvant platinum-based chemotherapy improves disease-free survival and metastasis-free survival in patients with upper tract urothelial carcinoma.
Surgical Challenges Remain Among Recent Successes in Kidney Cancer
Hyung L. Kim, MD, discusses perioperative systemic therapy for patients with kidney cancer.
Standardization, Simplification Needed for Wider Adoption of Robotic Cystectomy
Amit Gupta, MD, discusses the superiority of robotic cystectomy compared with open cystectomies and its relevance in the current treatment landscape of bladder cancer.
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