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Dr. Dirk Arnold on Sirflox Study Results in Colorectal Cancer

Dirk Arnold, MD
Published: Thursday, Jul 02, 2015



Dirk Arnold, MD, director of the Department of Medical Oncology at Klinik für Tumorbiologie, Freiburg, Germany, discusses the phase III Sirflox study, which looked at selective internal radiation therapy (SIRT) using Yttrium-90 (Y-90) resin microspheres for the treatment of metastatic colorectal cancer.

The trial included 530 randomized patients, half that received standard chemotherapy, which is FOLFOX6 with or without bevacizumab. The other half received Y-90 SIRT, which was given after the first or second administration of FOLFOX6 with or without bevacizumab. This treatment is for the palliative patient, said Arnold.

The results were surprising, said Arnold. There was no improvement in progression-free survival when all patients were taken into consideration. However, progression of the liver was significantly reduced with SIRT. This may be because many of the patients in the trial had disease in more than just the liver, which was not effected by the SIRT, said Arnold.

<<< View more from the 2015 World GI Congress



Dirk Arnold, MD, director of the Department of Medical Oncology at Klinik für Tumorbiologie, Freiburg, Germany, discusses the phase III Sirflox study, which looked at selective internal radiation therapy (SIRT) using Yttrium-90 (Y-90) resin microspheres for the treatment of metastatic colorectal cancer.

The trial included 530 randomized patients, half that received standard chemotherapy, which is FOLFOX6 with or without bevacizumab. The other half received Y-90 SIRT, which was given after the first or second administration of FOLFOX6 with or without bevacizumab. This treatment is for the palliative patient, said Arnold.

The results were surprising, said Arnold. There was no improvement in progression-free survival when all patients were taken into consideration. However, progression of the liver was significantly reduced with SIRT. This may be because many of the patients in the trial had disease in more than just the liver, which was not effected by the SIRT, said Arnold.

<<< View more from the 2015 World GI Congress


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