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Dr. Heymach on New KRAS Subsets in Lung Cancer

John Heymach, MD, PhD
Published: Sunday, Apr 19, 2015



John Heymach, MD, PhD, chair of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, discusses a study on KRAS mutations in lung cancer, which led to the identification of three more KRAS subsets.

Heymach says that KRAS-mutant lung cancer and treatment for it is the number one problem in this specific field. In this study, researchers examined KRAS with techniques such as DNA sequencing, mRNA sequencing, immune profiling and proteomics.

It was discovered that KRAS can be broken down into three major subgroups. These groups are believed to be caused by additional mutations, such as P53.

Because of these identified subgroups, Heymach says researchers can now see how they each respond to treatments. In the past, targeted therapies for KRAS mutations were not often effective, but Heymach adds this may change through focusing on a specific subgroup versus KRAS as a whole.

<<< View more from the 2015 AACR Annual Meeting



John Heymach, MD, PhD, chair of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, discusses a study on KRAS mutations in lung cancer, which led to the identification of three more KRAS subsets.

Heymach says that KRAS-mutant lung cancer and treatment for it is the number one problem in this specific field. In this study, researchers examined KRAS with techniques such as DNA sequencing, mRNA sequencing, immune profiling and proteomics.

It was discovered that KRAS can be broken down into three major subgroups. These groups are believed to be caused by additional mutations, such as P53.

Because of these identified subgroups, Heymach says researchers can now see how they each respond to treatments. In the past, targeted therapies for KRAS mutations were not often effective, but Heymach adds this may change through focusing on a specific subgroup versus KRAS as a whole.

<<< View more from the 2015 AACR Annual Meeting




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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