Dr. Balar on Results of Durvalumab Plus Tremelimumab in Bladder Cancer

Arjun V. Balar, MD
Published: Monday, Apr 16, 2018



Arjun V. Balar, MD, assistant professor, Department of Medicine, director, Genitourinary Medical Oncology Program, NYU Langone’s Perlmutter Cancer Center, discusses the results of a study investigating durvalumab (Imfinzi) plus tremelimumab in patients with metastatic urothelial cancer.

Durvalumab is currently approved as a second-line therapy for patients with platinum-refractory metastatic urothelial cancer. The addition of CTLA-4 blockade with tremelimumab demonstrated benefit while maintaining a manageable safety profile.

At a median follow-up of 11.6 months, the overall response rate was 20.8% for the entire population. Responses based on PD-L1 status were also observed, says Balar. Patients whose tumors were considered PD-L1 high had a response rate of 29% and those who had a low PD-L1 expression had a response rate of 15%. This suggests that responses occurred across PD-L1 subgroups.


Arjun V. Balar, MD, assistant professor, Department of Medicine, director, Genitourinary Medical Oncology Program, NYU Langone’s Perlmutter Cancer Center, discusses the results of a study investigating durvalumab (Imfinzi) plus tremelimumab in patients with metastatic urothelial cancer.

Durvalumab is currently approved as a second-line therapy for patients with platinum-refractory metastatic urothelial cancer. The addition of CTLA-4 blockade with tremelimumab demonstrated benefit while maintaining a manageable safety profile.

At a median follow-up of 11.6 months, the overall response rate was 20.8% for the entire population. Responses based on PD-L1 status were also observed, says Balar. Patients whose tumors were considered PD-L1 high had a response rate of 29% and those who had a low PD-L1 expression had a response rate of 15%. This suggests that responses occurred across PD-L1 subgroups.



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Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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