ONCLIVE NEWS NETWORK: ON LOCATION WILL BE LIVE AT ESMO THIS WEEK - STAY TUNED FOR MORE INFORMATION!

Dr. Chapman on BRAF/MEK Combination for Melanoma

Paul Chapman, MD
Published: Wednesday, May 16, 2012

Paul B. Chapman, MD, medical oncologist, Memorial Sloan-Kettering Cancer Center, discusses combination therapy with dabrafenib and trametinib, two investigational agents for patients with advanced melanoma that have a V600 BRAF mutation.

An expanded Phase IB trial to be presented as ASCO shows that combination therapy with the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib stalls cancer progression with fewer side effects than a single-agent BRAF-targeted therapy.

Based on the rational behind this trial, Chapman is optimistic that this combination will result in a prolonged response. With a single BRAF inhibitor, approximately half of patients develop resistant within five to six months. With the addition of the MEK inhibitor, ideally the time to resistance would be increased, but this data has not yet matured.

As more data becomes available, Chapman hopes that this combination results in a higher response rate or a higher incidence of complete responses. A larger trial is likely to follow, but the the phase IB trial has set the stage for the efficacy of this combination.

<<< View more from the 2012 ASCO Conference

Paul B. Chapman, MD, medical oncologist, Memorial Sloan-Kettering Cancer Center, discusses combination therapy with dabrafenib and trametinib, two investigational agents for patients with advanced melanoma that have a V600 BRAF mutation.

An expanded Phase IB trial to be presented as ASCO shows that combination therapy with the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib stalls cancer progression with fewer side effects than a single-agent BRAF-targeted therapy.

Based on the rational behind this trial, Chapman is optimistic that this combination will result in a prolonged response. With a single BRAF inhibitor, approximately half of patients develop resistant within five to six months. With the addition of the MEK inhibitor, ideally the time to resistance would be increased, but this data has not yet matured.

As more data becomes available, Chapman hopes that this combination results in a higher response rate or a higher incidence of complete responses. A larger trial is likely to follow, but the the phase IB trial has set the stage for the efficacy of this combination.

<<< View more from the 2012 ASCO Conference


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Advances in™ Melanoma: Exploring BRAF/MEK in Adjuvant and Neoadjuvant SettingsSep 28, 20191.5
Publication Bottom Border
Border Publication
x