Dr. Cristofanilli on the PALOMA3 Trial for Breast Cancer

Massimo Cristofanilli, MD
Published: Wednesday, Jun 03, 2015



Massimo Cristofanilli, MD, Jefferson University Physician, professor, director, Breast Care Center, Jefferson University Hospital, discusses the PALOMA3 trial.

The randomized, placebo-controlled phase III study examined palbociclib plus fulvestrant in pre- and post-menopausal patients with ER-positive breast cancer. The first analysis demonstrated that the primary endpoint, which was progression-free survival (PFS), had been reached. In the combination arm, PFS was 9.2 months compared to 3.8 months in the control arm, Cristofanilli says.

Patients treated with the combination previously failed endocrine therapy in the metastatic setting. One line of chemotherapy in the metastatic setting was permitted. Results of the study showed that the addition of palbociclib to fulvestrant is a more effective treatment versus fulvestrant alone, Cristofanilli says.

<<< View more from the 2015 ASCO Annual Meeting



Massimo Cristofanilli, MD, Jefferson University Physician, professor, director, Breast Care Center, Jefferson University Hospital, discusses the PALOMA3 trial.

The randomized, placebo-controlled phase III study examined palbociclib plus fulvestrant in pre- and post-menopausal patients with ER-positive breast cancer. The first analysis demonstrated that the primary endpoint, which was progression-free survival (PFS), had been reached. In the combination arm, PFS was 9.2 months compared to 3.8 months in the control arm, Cristofanilli says.

Patients treated with the combination previously failed endocrine therapy in the metastatic setting. One line of chemotherapy in the metastatic setting was permitted. Results of the study showed that the addition of palbociclib to fulvestrant is a more effective treatment versus fulvestrant alone, Cristofanilli says.

<<< View more from the 2015 ASCO Annual Meeting


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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