VISIT US IN CHICAGO JUNE 2-4 AT BOOTH 2073!

Dr. Kumar on Managing Toxicities in the MLN9708 Study

Shaji K. Kumar, MD
Published: Sunday, Dec 09, 2012

Shaji K. Kumar, MD, Division of Hematology, Mayo Clinic, talks about managing toxicities in the MLN9708 study.

Kumar was the lead author on a phase I/II study analyzing MLN9708 in combination with lenalidomide and dexamethasone in previously untreated multiple myeloma patients. The study found that the recommended phase II dose showed antitumor activity and was well tolerated, with one peripheral neuropathy.

In most treatments, Kumar says, the main way to manage toxicity is to decrease the dosage. In the two patients that experienced peripheral neuropathy in the trial, their dosage was decreased and their condition improved.

<<< View coverage from the 2012 ASH Meeting

Shaji K. Kumar, MD, Division of Hematology, Mayo Clinic, talks about managing toxicities in the MLN9708 study.

Kumar was the lead author on a phase I/II study analyzing MLN9708 in combination with lenalidomide and dexamethasone in previously untreated multiple myeloma patients. The study found that the recommended phase II dose showed antitumor activity and was well tolerated, with one peripheral neuropathy.

In most treatments, Kumar says, the main way to manage toxicity is to decrease the dosage. In the two patients that experienced peripheral neuropathy in the trial, their dosage was decreased and their condition improved.

<<< View coverage from the 2012 ASH Meeting


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
34th Annual Miami Breast Cancer Conference® Clinical Case Vignette Series™May 25, 20182.0
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Publication Bottom Border
Border Publication
x