Dr. Raffaele Califano on Immunotherapy in Small-Cell Lung Cancer

Raffaele Califano, MD
Published: Saturday, Apr 16, 2016



Raffaele Califano, MD, consultant in medical oncology at the Christie NHS Foundation Trust and University Hospital of South Manchester, discuses the potential for immunotherapy in small-cell lung cancer (SCLC).

Several studies have investigated checkpoint inhibitors in SCLC, says Califano. These include the Checkmate 032, which looked at nivolumab either alone or with ipilimumab. The single-agent nivolumab arm demonstrated an 18% response rate, says Califano. The disease-free survival rate was 54% for the combination arm.

Based on this data there are now trials ongoing looking at nivolomab as a second-line treatment in patients with small-cell lung cancer.

The checkpoint inhibitor pembrolizumab was also investigated in SCLC as a single agent in the Keynote-28 study. In this study, patients were selected based on PD-L1 expression, explains Califano. The overall response rate was 35%, high for this patient population, he says, and the drug was very well tolerated.

A number of other studies looking at pembrolizimab have been launched, which are investigating it as both a single-agent and a maintenance treatment. Immunotherapy offers significant promise for this patient population, which does not have many other treatment options, says Califano.

<<< View more from the 2016 European Lung Cancer Conference



Raffaele Califano, MD, consultant in medical oncology at the Christie NHS Foundation Trust and University Hospital of South Manchester, discuses the potential for immunotherapy in small-cell lung cancer (SCLC).

Several studies have investigated checkpoint inhibitors in SCLC, says Califano. These include the Checkmate 032, which looked at nivolumab either alone or with ipilimumab. The single-agent nivolumab arm demonstrated an 18% response rate, says Califano. The disease-free survival rate was 54% for the combination arm.

Based on this data there are now trials ongoing looking at nivolomab as a second-line treatment in patients with small-cell lung cancer.

The checkpoint inhibitor pembrolizumab was also investigated in SCLC as a single agent in the Keynote-28 study. In this study, patients were selected based on PD-L1 expression, explains Califano. The overall response rate was 35%, high for this patient population, he says, and the drug was very well tolerated.

A number of other studies looking at pembrolizimab have been launched, which are investigating it as both a single-agent and a maintenance treatment. Immunotherapy offers significant promise for this patient population, which does not have many other treatment options, says Califano.

<<< View more from the 2016 European Lung Cancer Conference


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