Dr. Yang on Osimertinib as First-Line Therapy for EGFR-Positive NSCLC

James Yang, MD
Published: Saturday, Apr 13, 2019



James Chih-Hsin Yang, MD, director, Graduate Institute of Oncology, director, Department of Oncology at National Taiwan University Hospital, discusses the final safety and efficacy results from 2 phase I expansion cohorts from the phase I/II AURA trial (NCT01802632). Both cohorts received osimertinib (Tagrisso) at a dose of either 80 mg or 160 mg for advanced EGFR mutation-positive advanced non–small cell lung cancer (NSCLC).

For the trial, investigators sought to determine the durability of response for these patients. Results showed that the response rate has been high for both groups, at 67% and 87% for the 80-mg cohort and the 160-mg cohort, respectively. The median duration of response is approximately 20 months, which Yang explained is consistent with findings from the phase III FLAURA trial (NCT02296125).

At the time of data cutoff, May 1, 2018, 11 patients were still receiving the study drug. At 3 years, 25% of patients were still receiving treatment, and at 4 years, 18% of patients had durable response. In terms of progression-free survival, at a cutoff of 3 months, 20% of patients were progression-free. At 4 years, 14% of patients are still progression-free, as estimated by Kaplan–Meier curves. These results, Yang explains, provide confidence that osimertinib may induce durable response in at least some of these patients in the first line.

  <<< 2019 European Lung Cancer Congress


James Chih-Hsin Yang, MD, director, Graduate Institute of Oncology, director, Department of Oncology at National Taiwan University Hospital, discusses the final safety and efficacy results from 2 phase I expansion cohorts from the phase I/II AURA trial (NCT01802632). Both cohorts received osimertinib (Tagrisso) at a dose of either 80 mg or 160 mg for advanced EGFR mutation-positive advanced non–small cell lung cancer (NSCLC).

For the trial, investigators sought to determine the durability of response for these patients. Results showed that the response rate has been high for both groups, at 67% and 87% for the 80-mg cohort and the 160-mg cohort, respectively. The median duration of response is approximately 20 months, which Yang explained is consistent with findings from the phase III FLAURA trial (NCT02296125).

At the time of data cutoff, May 1, 2018, 11 patients were still receiving the study drug. At 3 years, 25% of patients were still receiving treatment, and at 4 years, 18% of patients had durable response. In terms of progression-free survival, at a cutoff of 3 months, 20% of patients were progression-free. At 4 years, 14% of patients are still progression-free, as estimated by Kaplan–Meier curves. These results, Yang explains, provide confidence that osimertinib may induce durable response in at least some of these patients in the first line.

  <<< 2019 European Lung Cancer Congress

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Online CME Activities
TitleExpiration DateCME Credits
Online Medical Crossfire®: 5th Annual Miami Lung Cancer ConferenceMay 30, 20196.5
Community Practice Connections™: Working Group for Changing Standards in EGFR-Mutated Lung Cancers: Real-World Applications of the Evidence for NursesJun 29, 20191.5
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