Dr. Mirza on the Phase III NOVA Trial in Ovarian Cancer

Mansoor Raza Mirza, MD
Published: Sunday, Oct 09, 2016



Mansoor Raza Mirza, MD, chief oncologist, Rigshospitalet, Copenhagen University Hospital, discusses the results of the phase III NOVA trial during an interview at the 2016 ESMO Congress.

The study randomized patients in a 2:1 ratio across 2 independent cohorts. In the first cohort, patients with germline BRCA mutations received the PARP inhibitor niraparib at 300 mg daily or placebo. In the second cohort, patients with non-germline BRCA-mutant tumors received the agent or placebo.

After a median follow-up of 16.9 months, the median progression-free survival with niraparib was 21 months compared with 5.5 months for placebo in patients with germline BRCA mutations. These results were, overall, clinically meaningful, explains Mirza.


Mansoor Raza Mirza, MD, chief oncologist, Rigshospitalet, Copenhagen University Hospital, discusses the results of the phase III NOVA trial during an interview at the 2016 ESMO Congress.

The study randomized patients in a 2:1 ratio across 2 independent cohorts. In the first cohort, patients with germline BRCA mutations received the PARP inhibitor niraparib at 300 mg daily or placebo. In the second cohort, patients with non-germline BRCA-mutant tumors received the agent or placebo.

After a median follow-up of 16.9 months, the median progression-free survival with niraparib was 21 months compared with 5.5 months for placebo in patients with germline BRCA mutations. These results were, overall, clinically meaningful, explains Mirza.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Oncology Best Practice™: Expert Perspectives to Incorporate Evidence on PARP Inhibitors into Practice and Optimize the Medical Management of Ovarian CancerOct 31, 20181.0
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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