Dr. Pal on RCS in Metastatic Urothelial Carcinoma

Sumanta Kumar Pal, MD
Published: Friday, Jan 31, 2014



Sumanta Kumar Pal, MD, assistant professor, genitourinary cancers, City of Hope, discusses a SEER database analysis that explored survival outcomes for patients with metastatic urothelial carcinoma (mUC).

The SEER database incorporates data from about 28% of the US population and is used across several studies to evaluate outcomes. In this specific analysis, changes in relative conditional survival (RCS), a statistical endpoint used to help predict survival, was utilized to determine the efficacy of second- and third-line treatments in mUC.

Treatments used after the frontline setting for patients with mUC are largely based on evidence from phase II trials. Unfortunately, this analysis established that many of these treatments used after the frontline setting do not result in major improvements in RCS, Pal states. This suggests that despite best efforts, these later lines of therapy might not be effecting a real change on the natural history of the disease.
View more on this study >>>

<<< View more from the 2014 GU Cancers Symposium



Sumanta Kumar Pal, MD, assistant professor, genitourinary cancers, City of Hope, discusses a SEER database analysis that explored survival outcomes for patients with metastatic urothelial carcinoma (mUC).

The SEER database incorporates data from about 28% of the US population and is used across several studies to evaluate outcomes. In this specific analysis, changes in relative conditional survival (RCS), a statistical endpoint used to help predict survival, was utilized to determine the efficacy of second- and third-line treatments in mUC.

Treatments used after the frontline setting for patients with mUC are largely based on evidence from phase II trials. Unfortunately, this analysis established that many of these treatments used after the frontline setting do not result in major improvements in RCS, Pal states. This suggests that despite best efforts, these later lines of therapy might not be effecting a real change on the natural history of the disease.
View more on this study >>>

<<< View more from the 2014 GU Cancers Symposium




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Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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