Dr. Plimack Discusses Trials Investigating Apalutamide, Enzalutamide in M0 CRPC

Elizabeth Plimack, MD
Published: Friday, Feb 09, 2018



Elizabeth Plimack, MD, director of Genitourinary Clinical Research at Fox Chase Cancer Center, discusses 2 studies reported at the 2018 Genitourinary Cancers Symposium in patients with nonmetastatic M0 castration-resistant prostate cancer (CRPC).

These patients show no evidence of metastatic disease on conventional imaging, but their PSA continues to rise, despite receiving androgen deprivation therapy, Plimack explains.

The phase III randomized, double-blind PROSPER study investigated enzalutamide (Xtandi) in these patients, and the phase III randomized, double-blind SPARTAN study looked at apalutamide (ARN-509).

Both trials showed a robust effect in terms of delay in time to metastases, but overall survival data have not yet shown a difference in treating early versus treating later. The question that remains is whether there is ultimately a long-term benefit in treating these patients earlier, in the M0 space, versus later, at M1, Plimack says.
 


Elizabeth Plimack, MD, director of Genitourinary Clinical Research at Fox Chase Cancer Center, discusses 2 studies reported at the 2018 Genitourinary Cancers Symposium in patients with nonmetastatic M0 castration-resistant prostate cancer (CRPC).

These patients show no evidence of metastatic disease on conventional imaging, but their PSA continues to rise, despite receiving androgen deprivation therapy, Plimack explains.

The phase III randomized, double-blind PROSPER study investigated enzalutamide (Xtandi) in these patients, and the phase III randomized, double-blind SPARTAN study looked at apalutamide (ARN-509).

Both trials showed a robust effect in terms of delay in time to metastases, but overall survival data have not yet shown a difference in treating early versus treating later. The question that remains is whether there is ultimately a long-term benefit in treating these patients earlier, in the M0 space, versus later, at M1, Plimack says.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Show Me the Data: The Experts Weigh-In on Evidence to Support Strategies for Classic Clinical Scenarios in Renal Cell CarcinomaAug 31, 20181.5
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