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Dr. Cohen on Biomarkers Associated With Response in Patients With HNSCC Treated With Afatinib

Ezra Cohen, MD
Published: Thursday, Feb 18, 2016



Ezra Cohen, MD, associate director, Moores Cancer Center,professor of Medicine, University of California, San Diego Health System, discusses tumor biomarker association with clinical outcomes in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with afatinib versus methotrexate.

In a biomarker analysis of the LUX-Head and Neck 1 study, researchers sought to determine which patients, whether HPV-positive or HPV-negative, are more likely to benefit from treatment with afatinib versus methotrexate, which is the standard of care, Cohen explains.

In patients who were p16-negative, the response rate with afatinib was approximately 14%; there were almost no responses with methotrexate in this subgroup, Cohen says. Secondly, patients with EGFR amplification had a higher benefit with afatinib. High levels of P10 and low levels of HER3 also served as biomarkers for patients who respond postiviely to afatinib, he adds.

<<< View more from the 2016 Multidisciplinary Head and Neck Cancer Symposium



Ezra Cohen, MD, associate director, Moores Cancer Center,professor of Medicine, University of California, San Diego Health System, discusses tumor biomarker association with clinical outcomes in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with afatinib versus methotrexate.

In a biomarker analysis of the LUX-Head and Neck 1 study, researchers sought to determine which patients, whether HPV-positive or HPV-negative, are more likely to benefit from treatment with afatinib versus methotrexate, which is the standard of care, Cohen explains.

In patients who were p16-negative, the response rate with afatinib was approximately 14%; there were almost no responses with methotrexate in this subgroup, Cohen says. Secondly, patients with EGFR amplification had a higher benefit with afatinib. High levels of P10 and low levels of HER3 also served as biomarkers for patients who respond postiviely to afatinib, he adds.

<<< View more from the 2016 Multidisciplinary Head and Neck Cancer Symposium


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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