Lori Goldstein, MD, director, The Naomi and Phil Lippincott Breast Evaluation Center, deputy associate director, Clinical Research, Fox Chase Cancer Center, discusses mechanisms of resistance to endocrine therapy.
Some mechanisms of resistance to endocrine therapy have to do with ER co-regulation and downstream effects (signaling transduction interaction) with PI3K, AKT3, and MAPK. In her presentation at the 13th Annual International Congress on the Future of Breast CancerÂ®
, Goldstein discussed new agents and new opportunities in this space: mTOR, HDAC, and CDK4/6 inhibitors.
Goldstein notes that there is also earlier data in the areas of SARC inhibition and androgen synthesis inhibition.