Molecular Testing, Immunotherapy To Be Highlighted at 20th Annual Breast Cancer Conference

Angelica Welch and Gina Columbus
Published: Friday, Sep 28, 2018

Ruth O'Regan, MD
Ruth O'Regan, MD
Advances in subtype-specific treatments, immunotherapy, ongoing issues with younger patients, the optimal use of neoadjuvant and adjuvant regimens, and molecular testing will all be at the forefront of discussion during the 20th Annual Lynn Sage Breast Cancer Symposium.

The meeting, which is organized by the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, will take place October 11 to 14, 2018, in Chicago, Illinois. Annually, the program features oncologists in medical, surgical, and radiation specialties, who evaluate the current approaches in practice and share insight on developments in the breast cancer pipeline.

William J. Gradishar, MD, chief of hematology and oncology in the Department of Medicine, Betsy Bramsen Professorship of Breast Oncology, and professor of medicine (hematology and oncology), of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, is chair of this year’s symposium. One of the two keynote presentations will include Gradishar’s lecture, “A Frontline View of the Last 20 Years and Where We Go Next,” which will highlight the evolution of breast cancer treatment and hopeful advances going forward.

"Overall, there are going to be very nice sessions for triple-negative breast cancer and local therapy–based subtypes," said Ruth O'Regan, MD, a 2018 Lynn Sage Breast Cancer Symposium faculty member. "Dr Gradishar is going to show all of the successes that we have had in breast cancer over the past 20 years, so that will be very exciting."

Moving the Needle Forward With Molecular Testing

Molecular testing is an additional topic being more frequently considered in the breast cancer landscape, as it can help identify which patients may be eligible for less-intensive treatment regimens. At the 2018 ASCO Annual Meeting, findings of the phase III TAILORx trial demonstrated that adjuvant endocrine therapy alone is noninferior to adjuvant chemoendocrine therapy in patients with hormone receptor–positive, HER2-negative, node-negative early-stage breast cancer who have an intermediate risk of distant recurrence based on the Oncotype DX Breast Recurrence Score test.

The data are significant, investigators noted, as it can allow thousands of patients to avoid overtreatment with chemotherapy. The noninferiority of endocrine therapy alone compared with endocrine therapy plus chemotherapy (HR, 1.08; 95% CI, 0.94-1.24; P = .26) met the trial’s primary endpoint.1

However, O’Regan, a professor of medicine at University of Wisconsin School of Medicine and Carbone Cancer Center, did note that while the findings are significant, it is not necessarily enough to change practice.

"The fact that overall, the trial showed no benefit in adding chemotherapy to endocrine therapy, is an enormous advance in breast cancer," said O'Regan. "Although it is confirmatory and really important, and will expand the use of this testing so more women can avoid chemotherapy, it is not a practice-changing trial. But anyone can be convinced by these data that this test is very important and should be routine for patients with node-negative estrogen receptor–positive breast cancer."

Oncotype DX is a 21-tumor gene expression assay designed to predict the need for chemotherapy based on patient scores from 0 to 100. Those with a score of 26 to 100 are found to benefit from the addition of chemotherapy to endocrine therapy. However, patients with a score of 0 to 10, defined as a low risk of recurrence, derive minimal to no benefit from added chemotherapy. The benefit of added chemotherapy has been uncertain for patients with intermediate risk (11-25).2

"The talks on genomic testing are going to be interesting because there is going to be an update to the [National Comprehensive Cancer Network] guidelines as far as early-stage breast cancer soon," said O'Regan. "The one that has the most prediction in terms of who needs chemotherapy in the node-negative setting is clearly the Oncotype DX test. That being said, there are a number of assays, including MammaPrint, that are prognostic and are able to identify a group of women who have a very low risk of recurrence."

Potential With Immunotherapy

Immunotherapy will also be a focus of the meeting, following recent clinical trials that have demonstrated benefit with checkpoint inhibitors in select patients, specifically those with triple-negative breast cancer (TNBC). The Connie Moskow Memorial Lecture, “Immunology and Breast Cancer,” will be presented by Mary Disis, MD, director of Tumor Vaccine Medical Oncology, Department of Medicine, Division of Oncology, University of Washington Medicine.

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