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Dr. Sledge on Using Tumor Heterogeneity to Guide Treatment in Breast Cancer

George W. Sledge, Jr., MD
Published: Saturday, Feb 28, 2015



George W. Sledge, Jr., MD, professor of medicine, Stanford University School of Medicine, explains how tumor heterogeneity impacts patient care and research.

Sledge says within a primary breast cancer, the tumor can express different sensitivities. This brings up a challenging question for physicians about which sensitivity to target. Guidelines help physicians define the tumor type, Sledge says.

In the metastatic setting, significant differences can exist between the primary tumor and the first site of metastasis. This is due in part to the cancer changing in an attempt to resist therapy. Sledge says it is important to rebiopsy patients at the time of metastatic disease in order to better treat the cancer.

<<< View more from the 32nd Annual Miami Breast Cancer Conference



George W. Sledge, Jr., MD, professor of medicine, Stanford University School of Medicine, explains how tumor heterogeneity impacts patient care and research.

Sledge says within a primary breast cancer, the tumor can express different sensitivities. This brings up a challenging question for physicians about which sensitivity to target. Guidelines help physicians define the tumor type, Sledge says.

In the metastatic setting, significant differences can exist between the primary tumor and the first site of metastasis. This is due in part to the cancer changing in an attempt to resist therapy. Sledge says it is important to rebiopsy patients at the time of metastatic disease in order to better treat the cancer.

<<< View more from the 32nd Annual Miami Breast Cancer Conference


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
34th Annual Miami Breast Cancer Conference® Clinical Case Vignette Series™May 25, 20182.0
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
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