Dr. Jahanzeb on the APHINITY and ExteNET Trials in Breast Cancer

Mohammad Jahanzeb, MD
Published: Thursday, Mar 09, 2017


Mohammad Jahanzeb, MD, professor of Clinical Medicine, Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, discusses the APHINITY and ExteNET studies in breast cancer.
 
The APHINITY study investigated the dual HER2 blockade of pertuzumab (Perjeta) and trastuzumab (Herceptin) plus chemotherapy. In the metastatic setting, there was data showing these 2 antibodies result in some additional toxicities, however, they have not been shown to cause much incremental cardiotoxicity, Jahanzeb explains.
 
The trial completed accrual in August of 2013, and while results are expected this year, they are not yet available. However, Jahanzeb says, it has been announced that the results are positive.
 
Five-year data for the ExteNET study, which investigated neratinib following trastuzumab, also looks positive, similar to the previously reported 2-year and 3-year data, Jahanzeb says.

<<< View more from the 2017 Miami Breast Cancer Conference

Mohammad Jahanzeb, MD, professor of Clinical Medicine, Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, discusses the APHINITY and ExteNET studies in breast cancer.
 
The APHINITY study investigated the dual HER2 blockade of pertuzumab (Perjeta) and trastuzumab (Herceptin) plus chemotherapy. In the metastatic setting, there was data showing these 2 antibodies result in some additional toxicities, however, they have not been shown to cause much incremental cardiotoxicity, Jahanzeb explains.
 
The trial completed accrual in August of 2013, and while results are expected this year, they are not yet available. However, Jahanzeb says, it has been announced that the results are positive.
 
Five-year data for the ExteNET study, which investigated neratinib following trastuzumab, also looks positive, similar to the previously reported 2-year and 3-year data, Jahanzeb says.

<<< View more from the 2017 Miami Breast Cancer Conference

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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