Dr. Brahmer Discusses Frontline Single-Agent Pembrolizumab in Lung Cancer

Julie R. Brahmer, MD
Published: Saturday, Mar 10, 2018


Julie R. Brahmer, MD, associate professor of oncology, co-director of the Upper Aerodigestive Department, Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine, discusses pembrolizumab (Keytruda) in the first-line treatment of non–small cell lung cancer during the 5th Annual Miami Lung Cancer Conference.

The first-line treatment of non–small cell lung cancer has changed dramatically in the past year and a half, Brahmer says. Patients with high PD-L1 expression now have the opportunity to receive pembrolizumab as a single-agent treatment.

The KEYNOTE-024 study randomized patients without EGFR or ALK rearrangements to receive pembrolizumab or standard platinum-containing chemotherapy. Based on data seen over the past year, patients who received single-agent pembrolizumab upfront had a significant improvement in overall survival and progression-free survival. Brahmer highly recommends testing for PD-L1 status prior to starting therapy, and offering single-agent pembrolizumab if the patient has high PD-L1 expression.
 

Julie R. Brahmer, MD, associate professor of oncology, co-director of the Upper Aerodigestive Department, Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine, discusses pembrolizumab (Keytruda) in the first-line treatment of non–small cell lung cancer during the 5th Annual Miami Lung Cancer Conference.

The first-line treatment of non–small cell lung cancer has changed dramatically in the past year and a half, Brahmer says. Patients with high PD-L1 expression now have the opportunity to receive pembrolizumab as a single-agent treatment.

The KEYNOTE-024 study randomized patients without EGFR or ALK rearrangements to receive pembrolizumab or standard platinum-containing chemotherapy. Based on data seen over the past year, patients who received single-agent pembrolizumab upfront had a significant improvement in overall survival and progression-free survival. Brahmer highly recommends testing for PD-L1 status prior to starting therapy, and offering single-agent pembrolizumab if the patient has high PD-L1 expression.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Working Group to Optimize Outcomes in EGFR-mutated Lung Cancers: Evolving Concepts for Nurses to Facilitate and Improve Patient CareJun 30, 20181.5
Community Practice Connections™: 4th Annual Miami Lung Cancer Conference®Jun 30, 20187.0
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