Dr. de Groot Discusses Altiratinib as Potential Treatment for Glioblastoma

John F de Groot, MD
Published: Monday, Nov 17, 2014

John F de Groot, MD, neuro-oncologist, The University of Texas MD Anderson Cancer Center, discusses the efficacy of the novel c-MET inhibitor altiratinib in glioblastoma.

In a trial, mice were treated with altiratinib alone, bevacizumab alone, or a combination of the two agents. De Groot says the combination dramatically reduced tumor volume and tumor invasion.

De Groot speculates that the combination worked so well because it was able to block myeloid cell infiltration and reduce angiogenesis in order to decrease tumor cell invasion.

​

<<< View more from the 2014 Society for Neuro-Oncology Annual Meeting

John F de Groot, MD, neuro-oncologist, The University of Texas MD Anderson Cancer Center, discusses the efficacy of the novel c-MET inhibitor altiratinib in glioblastoma.

In a trial, mice were treated with altiratinib alone, bevacizumab alone, or a combination of the two agents. De Groot says the combination dramatically reduced tumor volume and tumor invasion.

De Groot speculates that the combination worked so well because it was able to block myeloid cell infiltration and reduce angiogenesis in order to decrease tumor cell invasion.

​

<<< View more from the 2014 Society for Neuro-Oncology Annual Meeting


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Provider and Caregiver Connection™: Addressing Patient Concerns While Managing GlioblastomaSep 29, 20182.0
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x