Dr. Umamaheswar Duvvuri on Impact of Multiple Genetic Mutations in Advanced Thyroid Cancer

Umamaheswar Duvvuri, MD, PhD
Published: Tuesday, Oct 20, 2015



Umamaheswar Duvvuri, MD, PhD, assistant professor of Otolaryngology (ENT) at the University of Pittsburgh Medical Center, talks about potential genetic signatures for locally advanced, well-differentiated thyroid cancers.

Through the use of next-generation sequencing, it was determined that advanced thyroid cancers are more likely to have multiple mutations than less advanced disease, explains Duvvuri.

Most commonly these advanced cancers seem to have a combination of a BRAF mutation as well as mutation of the promoter region of telomerase reverse transcriptase (hTERT). This may indicate that these two mutations together can cause more aggressive thyroid cancers to form, says Duvvuri.

<<< View more from the 2015 International Thyroid Congress



Umamaheswar Duvvuri, MD, PhD, assistant professor of Otolaryngology (ENT) at the University of Pittsburgh Medical Center, talks about potential genetic signatures for locally advanced, well-differentiated thyroid cancers.

Through the use of next-generation sequencing, it was determined that advanced thyroid cancers are more likely to have multiple mutations than less advanced disease, explains Duvvuri.

Most commonly these advanced cancers seem to have a combination of a BRAF mutation as well as mutation of the promoter region of telomerase reverse transcriptase (hTERT). This may indicate that these two mutations together can cause more aggressive thyroid cancers to form, says Duvvuri.

<<< View more from the 2015 International Thyroid Congress




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Rapid Reviews in Oncology®: Practice-Changing Data in Acute Myeloid Leukemia: A Rapid Update From Atlanta OnlineDec 21, 20182.0
Community Practice Connections™: 2nd Annual European Congress on Hematology™: Focus on Lymphoid MalignanciesDec 30, 20182.0
Publication Bottom Border
Border Publication
x