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FDA Approval of Brentuximab Vedotin Plus AVD in Classical Hodgkin Lymphoma

Gina Columbus
Published: Tuesday, Mar 20, 2018



Hello and welcome to OncLive News Network, Breaking News. I'm Gina Columbus.

The FDA has granted an approval to brentuximab vedotin (Adcetris) in combination with adriamycin, vinblastine, and dacarbazine as a frontline treatment for patients with advanced classical Hodgkin lymphoma.

The decision is based on findings from the phase III ECHELON-1 trial, in which brentuximab vedotin plus AVD compared with standard ABVD, known as AVD plus bleomycin, demonstrated superior progression-free survival.

In the study, the brentuximab vedotin regimen reduced the risk of progression, death, or initiation of new therapy by 23% versus ABVD. The 2-year modified PFS rate was 82.1% with brentuximab vedotin compared with 77.25% for standard chemotherapy.

The FDA granted a breakthrough therapy designation for brentuximab vedotin in combination with chemotherapy for frontline advanced classical Hodgkin lymphoma in October 2017.

For more breaking news, subscribe to email alerts from OncLive.com. Thank you for watching! I'm Gina Columbus.
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Hello and welcome to OncLive News Network, Breaking News. I'm Gina Columbus.

The FDA has granted an approval to brentuximab vedotin (Adcetris) in combination with adriamycin, vinblastine, and dacarbazine as a frontline treatment for patients with advanced classical Hodgkin lymphoma.

The decision is based on findings from the phase III ECHELON-1 trial, in which brentuximab vedotin plus AVD compared with standard ABVD, known as AVD plus bleomycin, demonstrated superior progression-free survival.

In the study, the brentuximab vedotin regimen reduced the risk of progression, death, or initiation of new therapy by 23% versus ABVD. The 2-year modified PFS rate was 82.1% with brentuximab vedotin compared with 77.25% for standard chemotherapy.

The FDA granted a breakthrough therapy designation for brentuximab vedotin in combination with chemotherapy for frontline advanced classical Hodgkin lymphoma in October 2017.

For more breaking news, subscribe to email alerts from OncLive.com. Thank you for watching! I'm Gina Columbus.
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