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Lenvatinib in Metastatic Renal Cell Carcinoma

Insights From: Prof. Bernard Escudier, MD, Institute Gustave Roussy; Susanne Osanto, MD, PhD, Leiden University Medical Center
Published: Monday, Feb 29, 2016


There are different approaches for overcoming resistance in metastatic renal cell carcinoma (mRCC), states Bernard Escudier, MD. One approach is to target some of the cytokines; another is to target fibroblast growth factor (FGF). Lenvatinib, which inhibits FGF and VEGF, has been tested to try to overcome resistance in mRCC.

In a three-arm phase II study, lenvatinib in combination with everolimus improved progression-free survival by more than 7 months when compared with lenvatinib alone. Lenvatinib has a broad range of targets, says Susanne Osanto, MD. Phase III data are needed to confirm the efficacy in combination with everolimus. However, there tends to be a need to dose-reduce and/or interrupt treatment due to the toxicities with lenvatinib, notes Escudier.
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There are different approaches for overcoming resistance in metastatic renal cell carcinoma (mRCC), states Bernard Escudier, MD. One approach is to target some of the cytokines; another is to target fibroblast growth factor (FGF). Lenvatinib, which inhibits FGF and VEGF, has been tested to try to overcome resistance in mRCC.

In a three-arm phase II study, lenvatinib in combination with everolimus improved progression-free survival by more than 7 months when compared with lenvatinib alone. Lenvatinib has a broad range of targets, says Susanne Osanto, MD. Phase III data are needed to confirm the efficacy in combination with everolimus. However, there tends to be a need to dose-reduce and/or interrupt treatment due to the toxicities with lenvatinib, notes Escudier.
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