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The Future of Personalized Therapy in Advanced HCC

Insights From: Richard Finn, MD, David Geffen School of Medicine at UCLA
Published: Tuesday, Sep 10, 2019



Key Takeaways:

Novel approaches in the treatment of advanced hepatocellular carcinoma, such as using modified T-cell receptors to attack liver tumors with alpha fetoprotein expression.

Biomarker-based approaches to target the FGF19–FGFR4 signaling pathway, with a new generation of molecules in patients with hepatocellular carcinoma and high-FGF19 amplification or expression.

Moving toward a more personalized approach in the treatment of hepatocellular carcinoma.

Ensuring patients with hepatocellular carcinoma are not decompensated during initial locoregional therapy, so they may benefit from the sequencing of current and future therapies.

 
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Key Takeaways:

Novel approaches in the treatment of advanced hepatocellular carcinoma, such as using modified T-cell receptors to attack liver tumors with alpha fetoprotein expression.

Biomarker-based approaches to target the FGF19–FGFR4 signaling pathway, with a new generation of molecules in patients with hepatocellular carcinoma and high-FGF19 amplification or expression.

Moving toward a more personalized approach in the treatment of hepatocellular carcinoma.

Ensuring patients with hepatocellular carcinoma are not decompensated during initial locoregional therapy, so they may benefit from the sequencing of current and future therapies.

 
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