Dr. Shaw Describes LDK378 in ALK-Positive Lung Cancer

Video

Alice T. Shaw, MD, PhD, from the Massachusetts General Hospital Cancer Center, discusses the clinical activity of the ALK inhibitor LDK378 in patients with non-small cell lung cancer harboring an ALK alteration.

Alice T. Shaw, MD, PhD, an attending physician in the Center for Thoracic Cancers at Massachusetts General Hospital, discusses the clinical activity of the ALK inhibitor LDK378 in patients with non-small cell lung cancer (NSCLC) harboring an ALK alteration.

In crizotinib resistant patients, the response rate was approximately 60%, Shaw suggests. Additionally, 20%-30% of patients responded but did not meet the criteria for response. The duration of response to LDK378 was impressive, Shaw says. The median progression-free survival for those who were resistant to crizotinib was slightly over 8 months, which is similar to the benefit experienced with crizotinib.

Shaw believes the potential to salvage patients who progress on crizotinib with LDK378 is encouraging. Based on these data, LDK378 was granted breakthrough therapy designation by the FDA, which is a good indication for the efficacy of the agent, Shaw believes.

Related Videos
Ricardo D. Parrondo, MD, hematologist/oncologist, Mayo Clinic
Ilyas Sahin, MD
Raj Singh, MD
Jaime R. Merchán, MD, professor, co-leader, Translational and Clinical Oncology Research Program, director, Phase 1 Clinical Trials Program, Department of Medicine, Division of Medical Oncology, the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center
Saad J. Kenderian, MB, CHB
Tycel Phillips, MD
Minesh Mehta, MD
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,