Dr. Backes on Rationale for Lenvatinib and Weekly Paclitaxel in Endometrial Cancer

Floor J. Backes, MD
Published: Monday, Oct 14, 2019



Floor J. Backes, MD, associate professor, Division of Gynecologic Oncology, at The Ohio State University Comprehensive Cancer Center, discusses the rationale and results from a phase I study exploring lenvatinib (Lenvima) and weekly paclitaxel in women with recurrent endometrial cancer. 
 
The efficacy of weekly paclitaxel was largely unknown in this patient population, says Backes. However, anti-VEGF agents had shown prior activity in endometrial cancer. In the trial, investigators reported an objective response rate of 50% in patients with endometrial cancer, says Backes. Additionally, median progression-free survival was 12.8 months.  
 
The study also suggested that the combination was well tolerated. Though, the most common grade ≥ 3 adverse events included hypertension, neutropenia, leukopenia, and anemia.
 
In the trial, investigators established a recommended phase II dose of 16 mg of daily lenvatinib and 80 mg/m2 of weekly paclitaxel. 
 
These results suggest benefit for this patient population; however, further testing in a larger clinical trial is necessary. 
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Floor J. Backes, MD, associate professor, Division of Gynecologic Oncology, at The Ohio State University Comprehensive Cancer Center, discusses the rationale and results from a phase I study exploring lenvatinib (Lenvima) and weekly paclitaxel in women with recurrent endometrial cancer. 
 
The efficacy of weekly paclitaxel was largely unknown in this patient population, says Backes. However, anti-VEGF agents had shown prior activity in endometrial cancer. In the trial, investigators reported an objective response rate of 50% in patients with endometrial cancer, says Backes. Additionally, median progression-free survival was 12.8 months.  
 
The study also suggested that the combination was well tolerated. Though, the most common grade ≥ 3 adverse events included hypertension, neutropenia, leukopenia, and anemia.
 
In the trial, investigators established a recommended phase II dose of 16 mg of daily lenvatinib and 80 mg/m2 of weekly paclitaxel. 
 
These results suggest benefit for this patient population; however, further testing in a larger clinical trial is necessary. 



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