Dr. Beer on the Immune-Related Adverse Events of Ipilimumab in mCRPC

Tomasz Beer, MD
Published: Friday, May 16, 2014

Tomasz Beer, MD, FACP, professor of medicine, deputy director of the Knight Cancer Institute, Oregon Health and Science University, characterizes the immune-related adverse events associated with ipilimumab in a phase III metastatic castration-resistant prostate cancer trial.

Beer says the study was an analysis of the results of the first, large, randomized study of ipilimumab in advanced prostate cancer. Ipilimumab is an immune modulator that works by breaking tolerance and stimulating the immune system so that it can recognize and attack the prostate cancer.

Since ipilimumab is not specific to a cancer antigen, Beer says, it causes side effects that are related to an overactive immune system. Data from the analysis, which was presented at the 2014 Genitourinary Cancers Symposium, showed that the side effect profile of ipilimumab in prostate cancer is similar to what was previously described in melanoma, where the drug is approved.

Beer says standard approaches to the management of these side effects are almost always effective.
 
Tomasz Beer, MD, FACP, professor of medicine, deputy director of the Knight Cancer Institute, Oregon Health and Science University, characterizes the immune-related adverse events associated with ipilimumab in a phase III metastatic castration-resistant prostate cancer trial.

Beer says the study was an analysis of the results of the first, large, randomized study of ipilimumab in advanced prostate cancer. Ipilimumab is an immune modulator that works by breaking tolerance and stimulating the immune system so that it can recognize and attack the prostate cancer.

Since ipilimumab is not specific to a cancer antigen, Beer says, it causes side effects that are related to an overactive immune system. Data from the analysis, which was presented at the 2014 Genitourinary Cancers Symposium, showed that the side effect profile of ipilimumab in prostate cancer is similar to what was previously described in melanoma, where the drug is approved.

Beer says standard approaches to the management of these side effects are almost always effective.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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