Dr. Bendell on c-MET Inhibition in Hepatocellular Carcinoma

Johanna Bendell, MD
Published: Thursday, Feb 07, 2013

Johanna Bendell, MD, Director of GI Cancer Research Program, Associate Director, Drug Development Program, Sarah Cannon Research Institute, discusses c-MET inhibition in hepatocellular carcinoma (HCC).

A randomized phase II study compared tivantinib, a c-MET tyrosine kinase inhibitor (TKI), to best supportive care in the second-line setting for patients with advanced HCC. Patients with MET-high HCC saw improvement in progression-free survival and overall survival. There is a need for further exploration of anti-c-MET drugs for this patient population, Bendell says.

A phase I/II study from the 2013 Gastrointestinal Cancers Symposium combined E7050 (golvantinib), a c-MET and VEGFR TKI, with sorafenib, the standard of care for patients with advanced HCC. The phase I portion of the trial has been completed and is now moving on to phase II.

Johanna Bendell, MD, Director of GI Cancer Research Program, Associate Director, Drug Development Program, Sarah Cannon Research Institute, discusses c-MET inhibition in hepatocellular carcinoma (HCC).

A randomized phase II study compared tivantinib, a c-MET tyrosine kinase inhibitor (TKI), to best supportive care in the second-line setting for patients with advanced HCC. Patients with MET-high HCC saw improvement in progression-free survival and overall survival. There is a need for further exploration of anti-c-MET drugs for this patient population, Bendell says.

A phase I/II study from the 2013 Gastrointestinal Cancers Symposium combined E7050 (golvantinib), a c-MET and VEGFR TKI, with sorafenib, the standard of care for patients with advanced HCC. The phase I portion of the trial has been completed and is now moving on to phase II.




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