Dr. Berdeja Discusses the Future of Treatment for Myeloma

Jesus Berdeja, MD
Published: Friday, Feb 23, 2018



Jesus Berdeja, MD, director of Multiple Myeloma Research, Sarah Cannon Research Institute, discusses the future of treatment for patients with myeloma.

In 2018, there is a possibility that chimeric antigen receptor (CAR) T-cell therapies such as bb2121 will be approved in multiple myeloma, Berdeja says. The BCMA-directed CAR T-cell therapy bb2121 induced complete remissions for 56% of patients with relapsed/refractory multiple myeloma in the dose-escalation study presented at the 2017 ASH Annual Meeting. In this study, the objective response rate was 94%, which consisted of a very good partial response or better for 89% of patients.

Additionally, agents such as daratumumab (Darzalex) and selinexor may experience approvals in the frontline and relapsed/refractory settings, respectively. Similar to the lymphoma space, there is promise with antibody-drug conjugates and bispecific antibodies for the treatment of patients with multiple myeloma. Trials with these agents are currently ongoing.
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Jesus Berdeja, MD, director of Multiple Myeloma Research, Sarah Cannon Research Institute, discusses the future of treatment for patients with myeloma.

In 2018, there is a possibility that chimeric antigen receptor (CAR) T-cell therapies such as bb2121 will be approved in multiple myeloma, Berdeja says. The BCMA-directed CAR T-cell therapy bb2121 induced complete remissions for 56% of patients with relapsed/refractory multiple myeloma in the dose-escalation study presented at the 2017 ASH Annual Meeting. In this study, the objective response rate was 94%, which consisted of a very good partial response or better for 89% of patients.

Additionally, agents such as daratumumab (Darzalex) and selinexor may experience approvals in the frontline and relapsed/refractory settings, respectively. Similar to the lymphoma space, there is promise with antibody-drug conjugates and bispecific antibodies for the treatment of patients with multiple myeloma. Trials with these agents are currently ongoing.



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