Dr. Branagan on Vaccine to Better Protect Myeloma Patients From Flu

Andrew R. Branagan, MD
Published: Tuesday, Mar 29, 2016



Andrew R. Branagan, MD, postdoctoral associate in Medicine (Hematology), Yale Cancer Center, discusses the significance of a vaccine developed to better protect patients with multiple myeloma from getting the flu.

Researchers recently developed a vaccine strategy that reduces the risk of flu infections in patients with cancer who are at the highest risk. In a pilot study, patients with multiple myeloma received a high-dose flu vaccine followed by a second high-dose booster shot 1 month later. The regimen lowered the flu infection rate among patients from 20% to 6%, and improved protection against all flu strains covered by the vaccine in 66% of patients. If these results are confirmed in a randomized study, Branagan predicts it will have practice-changing implications and could change the dosing strategy in patients with plasma cell disorders.

Next steps, Branagan says, should include investigating the vaccine strategy in patients who have undergone transplantation.


Andrew R. Branagan, MD, postdoctoral associate in Medicine (Hematology), Yale Cancer Center, discusses the significance of a vaccine developed to better protect patients with multiple myeloma from getting the flu.

Researchers recently developed a vaccine strategy that reduces the risk of flu infections in patients with cancer who are at the highest risk. In a pilot study, patients with multiple myeloma received a high-dose flu vaccine followed by a second high-dose booster shot 1 month later. The regimen lowered the flu infection rate among patients from 20% to 6%, and improved protection against all flu strains covered by the vaccine in 66% of patients. If these results are confirmed in a randomized study, Branagan predicts it will have practice-changing implications and could change the dosing strategy in patients with plasma cell disorders.

Next steps, Branagan says, should include investigating the vaccine strategy in patients who have undergone transplantation.



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