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Dr. Carbone on Genetic Testing Availability and Accuracy

David P. Carbone, MD, PhD
Published: Thursday, Jul 25, 2013

David P. Carbone, MD, PhD, a professor in the Division of Medical Oncology at the Ohio State University Comprehensive Cancer Center, describes variations in the accuracy and availability of genetic testing technologies for patients with lung cancer.

Across the country, there is not only uneven access to genetic testing but also variations in accuracy, explains Carbone. Each test for EGFR is not the same, since some exclude rare mutations. As such, there is currently a transition under way in genetic testing with a potential transition to next-generation sequencing in the future.

Despite this transition, immunohistochemistry may be a better approach in some situations, since it can focus more on the protein. The ideal test, Carbone notes, would focus on the protein, since this is generally what is targeted by treatment. However, Carbone adds, at this point, protein-specific data and tests are less developed than genetic testing.

David P. Carbone, MD, PhD, a professor in the Division of Medical Oncology at the Ohio State University Comprehensive Cancer Center, describes variations in the accuracy and availability of genetic testing technologies for patients with lung cancer.

Across the country, there is not only uneven access to genetic testing but also variations in accuracy, explains Carbone. Each test for EGFR is not the same, since some exclude rare mutations. As such, there is currently a transition under way in genetic testing with a potential transition to next-generation sequencing in the future.

Despite this transition, immunohistochemistry may be a better approach in some situations, since it can focus more on the protein. The ideal test, Carbone notes, would focus on the protein, since this is generally what is targeted by treatment. However, Carbone adds, at this point, protein-specific data and tests are less developed than genetic testing.




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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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