Dr. Cheson on Novel ADCs in Non-Hodgkin Lymphoma

Bruce D. Cheson, MD
Published: Wednesday, Mar 20, 2013

Bruce D. Cheson, MD, Professor of Medicine, Head of Hematology, Director of Hematology Research, Georgetown Lombardi Comprehensive Cancer Center, discusses the prospect of using antibody drug conjugates (ADCs) in non-Hodgkin's lymphomas, including follicular lymphoma.

In phase I trials presented at the 2012 American Society of Hematology Annual Meeting, two ADCs targeting CD22 and CD79b, respectfully, showed single-agent activity in follicular and large cell lymphoma.

An ongoing randomized trial is analyzing the activity of these two agents in combination with rituximab. The study has crossover opportunities, providing information about cross resistance or lack thereof between the two agents, Cheson says. These trials have exciting possibilities and could be the first step to developing a drug similar to the ADC brentuximab in Hodgkin lymphoma.

Bruce D. Cheson, MD, Professor of Medicine, Head of Hematology, Director of Hematology Research, Georgetown Lombardi Comprehensive Cancer Center, discusses the prospect of using antibody drug conjugates (ADCs) in non-Hodgkin's lymphomas, including follicular lymphoma.

In phase I trials presented at the 2012 American Society of Hematology Annual Meeting, two ADCs targeting CD22 and CD79b, respectfully, showed single-agent activity in follicular and large cell lymphoma.

An ongoing randomized trial is analyzing the activity of these two agents in combination with rituximab. The study has crossover opportunities, providing information about cross resistance or lack thereof between the two agents, Cheson says. These trials have exciting possibilities and could be the first step to developing a drug similar to the ADC brentuximab in Hodgkin lymphoma.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Moving Forward From the Status Quo for the Treatment of Soft Tissue Sarcoma: Key Questions and New Answers to Optimize OutcomesOct 31, 20182.0
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x